Clorazepate dipotassium
Clorazepate Dipotassium, Tranxene (clorazepate dipotassium) is a small molecule pharmaceutical. Clorazepate dipotassium was first approved as Tranxene on 1982-01-01. It is used to treat alcohol withdrawal delirium, anxiety disorders, and partial epilepsies in the USA.
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Commercial
Therapeutic Areas
Trade Name
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Clorazepate dipotassium, Tranxene (discontinued: Clorazepate dipotassium, Gen-xene, Tranxene)
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Abbreviated New Drug Application (ANDA)
Clorazepate dipotassium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRANXENE | Key Therapeutics | N-017105 RX | 1982-01-01 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clorazepate dipotassium | ANDA | 2025-09-30 |
Indications
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Agency Specific
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Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | — | — | — | 1 | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | — | 1 | — | 1 |
| T-cell lymphoma | D016399 | — | — | — | — | — | 1 | — | 1 |
| T-cell lymphoma peripheral | D016411 | — | — | — | — | — | 1 | — | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | — | — | — | 1 | — | 1 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | — | — | — | 1 | — | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 1 | — | — | 1 |
| Headache | D006261 | — | R51 | — | — | 1 | — | — | 1 |
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | — | — | 1 | — | — | 1 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clorazepate dipotassium |
| INN | dipotassium clorazepate |
| Description | Clorazepic acid is a 1,4-benzodiazepinone in which the oxo group is at position 2, and which is substituted at positions 3, 5, and 7 by carboxy, phenyl and chloro groups, respectively. It has a role as a prodrug, an anticonvulsant, an anxiolytic drug and a GABA modulator. It is a conjugate acid of a clorazepic acid anion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C([O-])C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O.[K+].[K+].[OH-] |
Identifiers
| PDB | — |
| CAS-ID | 57109-90-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2096631 |
| ChEBI ID | 3762 |
| PubChem CID | 2809 |
| DrugBank | DB00628 |
| UNII ID | 63FN7G03XY (ChemIDplus, GSRS) |
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Additional graphs summarizing 307 documents
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Safety
Black-box Warning
Black-box warning for: Clorazepate dipotassium
Adverse Events
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2,710 adverse events reported
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